PANCE Exam Prep

Physician Assistant National Certifying

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Quiz

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Neurologic

A 40-year-old male presents with progressive personality changes, executive dysfunction, and apathy. Genetic testing reveals a mutation in the progranulin gene. Which neurodegenerative disorder is most consistent with his clinical picture?

Progranulin gene mutations are associated with frontotemporal lobar degeneration, which typically presents with marked personality and behavioral changes.